INTS6 antibody (AA 750-800)

Catalog No. ABIN7453687

This Rabbit Polyclonal antibody specifically detects INTS6 in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for INTS6 antibody (AA 750-800) (ABIN7453687)

Target: INTS6 (Integrator Complex Subunit 6 (INTS6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INTS6 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-INTS6 Antibody

Binding Specificity: AA 750-800

Purpose: Rabbit anti-DDX26/DICE1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 750 and 800

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for INTS6

Target: INTS6 (Integrator Complex Subunit 6 (INTS6))

Alternative Name: DDX26/DICE1

Background: Background: DDX26/DICE1 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX26/DICE1 is a subunit of the integrator complex involved in 3'-end processing of snRNAs. DDX26/DICE1 is implicated as a tumor suppressor, and its ectopic expression has been shown to inhibit tumor cell growth. Alternative names for DDX26/DICE1 include integrator complex subunit 6, Int6, protein deleted in cancer 1, protein DDX26, DBI-1, deleted in cancer 1, INTS6, DDX26A, HDB, Nochl2, and DKFZP434B105.

Gene ID: 26512

NCBI Accession: NP_036273

UniProt: Q9UL03