DERL1 antibody (AA 201-251)

Catalog No. ABIN7453690

This Rabbit Polyclonal antibody specifically detects DERL1 in WB, IP and IHC (fp). It exhibits reactivity toward Human and Mouse.

Quick Overview for DERL1 antibody (AA 201-251) (ABIN7453690)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DERL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-DERL1 Antibody

Binding Specificity: AA 201-251

Purpose: Rabbit anti-Derlin-1 Antibody, Affinity Purified

Predicted Reactivity: Bovine,Orangutan

Purification: Affinity Purified

Immunogen: between AA 201 and 251

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Alternative Name: Derlin-1

Background: Background: Derlin-1 (Degradation in endoplasmic reticulum protein 1) is a functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Derlin-1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome [taken from the Universal Protein Resource (UniProt) Q9BUN8].

Gene ID: 79139

NCBI Accession: NP_077271

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling