MBD2 antibody (AA 361-411)

Catalog No. ABIN7453726

This Rabbit Polyclonal antibody specifically detects MBD2 in WB, IP and IHC (fp). It exhibits reactivity toward Human and Mouse.

Quick Overview for MBD2 antibody (AA 361-411) (ABIN7453726)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-MBD2 Antibody

Binding Specificity: AA 361-411

Purpose: Rabbit anti-MBD2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 361 and 411

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Alternative Name: MBD2

Background: Background: MBD2 (methyl-CpG-binding domain protein 2) binds methylated CpG sites and represses gene transcription. DNA methylation is a common mechanism of gene silencing and is central to the developmental process. Methyl-CpG binding proteins (MBPs) have a high affinity for methylated DNA and are proposed to mediate gene silencing via the recruitment of histone deacetylases and other transcriptional repressors to chromatin.

Gene ID: 8932

NCBI Accession: NP_003918

UniProt: Q9UBB5

Pathways: Chromatin Binding