PRMT5 antibody (C-Term)

Catalog No. ABIN7453831

This Rabbit Polyclonal antibody specifically detects PRMT5 in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for PRMT5 antibody (C-Term) (ABIN7453831)

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRMT5 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-PRMT5 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-PRMT5 Antibody, Affinity Purified

Predicted Reactivity: X. laevis,Bovine,Orangutan

Purification: Affinity Purified

Immunogen: between AA 580 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended. Use rabbit anti-PRMT5 antibody ABIN7451315.

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PRMT5

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Alternative Name: PRMT5

Background: Background: Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). PRMT5 interacts with the SWI/SNF complexes and methylates histones H3 and H4. This finding suggests that PRMT5 is involved in the structural modification of chromatin and the regulation of gene transcription.

Gene ID: 10419

NCBI Accession: NP_006100

UniProt: O14744

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development