Recombinant Liver Arginase antibody (AA 1-322)

Catalog No. ABIN7453894

This Rabbit Monoclonal antibody specifically detects Liver Arginase in WB, IHC (fp) and IP. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant Liver Arginase antibody (AA 1-322) (ABIN7453894)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Liver Arginase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunoprecipitation (IP)

Clone: BLR161J

Product Details anti-Liver Arginase Antibody

Binding Specificity: AA 1-322

Purpose: Rabbit anti-Arginase 1 Recombinant Monoclonal Antibody [BLR161J]

Immunogen: residues 1-322 (FL)

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 20 μL/1 mg lysate

WB: 01:01,00

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Liver Arginase

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Alternative Name: Arginase 1

Background: Background: Arginase1 is a key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively, the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.  [taken from the Universal Protein Resource (UniProt) P05089].

Gene ID: 11846

NCBI Accession: NP_031508

UniProt: Q61176

Pathways: Cellular Response to Molecule of Bacterial Origin