CTNND1 antibody (AA 625-675)

Catalog No. ABIN7454382

This Rabbit Polyclonal antibody specifically detects CTNND1 in IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for CTNND1 antibody (AA 625-675) (ABIN7454382)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNND1 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-CTNND1 Antibody

Binding Specificity: AA 625-675

Purpose: Rabbit anti-CTNND1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 625 and 675

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with Tris-EDTA buffer pH 9.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-CTNND1 antibody A300-976A or A300-978A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Alternative Name: CTNND1

Background: Background: CTNND1 is an Armadillo repeat domain protein and member of the p120 protein family. The major function of CTNND1 involves the regulation of cadherins to influence cell-cell interactions. CTNND1 regulates cadherins by controlling cadherin turnover and/or trafficking. CTNND1 has also been found to play a role in the regulation of the actin cytoskeleton by modulating the activity of small GTPase Rho family members. CTNND1 is a substrate of the nonreceptor tyrosine kinase src and may play a role in the regulation of factors that regulate transcription.

Gene ID: 1500

NCBI Accession: NP_001322

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling