KIAA1524 antibody (AA 550-600)

Catalog No. ABIN7454404

The Rabbit Polyclonal anti-KIAA1524 antibody has been validated for IP and IHC (fp). It is suitable to detect KIAA1524 in samples from Human.

Quick Overview for KIAA1524 antibody (AA 550-600) (ABIN7454404)

Target: KIAA1524

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIAA1524 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-KIAA1524 Antibody

Binding Specificity: AA 550-600

Purpose: Rabbit anti-CIP2A Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 550 and 600

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-CIP2A antibody A301-454A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for KIAA1524

Target: KIAA1524

Alternative Name: CIP2A

Background: Background: CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.

Gene ID: 57650

NCBI Accession: NP_065941

UniProt: Q8TCG1