MSH6 antibody (C-Term)

Catalog No. ABIN7454511

This Rabbit Polyclonal antibody specifically detects MSH6 in WB and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for MSH6 antibody (C-Term) (ABIN7454511)

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-MSH6 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-MSH6 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1300 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC: 1:250 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MSH6

Target: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Alternative Name: MSH6

Background: Background: MSH6 is a component of the DNA mismatch repair (MMR) system that functions to recognize base-base mismatches and framshift mispairs. MSH6 forms a heterodimer with MSH2 and is also part of the BRCA1-associated genome surveillance complex (BASC). Mutations in MSH6 have been linked to endometrial carcinoma.

Gene ID: 2956

NCBI Accession: NP_000170

UniProt: P52701

Pathways: DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response