NOTCH2 antibody (AA 2421-2471)

Catalog No. ABIN7454805

This Rabbit Polyclonal antibody specifically detects NOTCH2 in WB, IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for NOTCH2 antibody (AA 2421-2471) (ABIN7454805)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-NOTCH2 Antibody

Binding Specificity: AA 2421-2471

Purpose: Rabbit anti-Notch2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 2421 and 2471

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Alternative Name: Notch2

Background: Background: Notch2 is a member of the Notch family of transmembrane receptors. The Notch gene was first reported as a drosophila gene responsible for the presence of notches in the wingblades of a specific strain of flies. The Notch proteins mediate juxtacrine signals between adjacent cells and regulate cell fate determination during development. In mammals there are 4 Notch receptors (Notch 1-4). Like Notch1, Notch 2 is required for embryo viability. Although Notch1 and Notch 2 are functionally similar, they may not serve redundant functions in the cell.

Gene ID: 4853

NCBI Accession: NP_077719

UniProt: Q04721

Pathways: Notch Signaling, Stem Cell Maintenance