Mre11 antibody (AA 658-708)

Catalog No. ABIN7454999

The Rabbit Polyclonal anti-Mre11 antibody (ABIN7454999) specifically detects Mre11 in WB, IP and IHC (fp). The antibody is reactive with Human samples.

Quick Overview for Mre11 antibody (AA 658-708) (ABIN7454999)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-Mre11 Antibody

Binding Specificity: AA 658-708

Purpose: Rabbit anti-Mre11 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 658 and 708

Isotype: IgG

Application Details

Application Notes:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Alternative Name: Mre11

Background: Background: Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3'- 5' exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.

Gene ID: 4361

NCBI Accession: NP_005582

UniProt: P49959

Pathways: DNA Damage Repair