Recombinant BCL6 antibody (AA 375-425)

Catalog No. ABIN7455109

The Rabbit Monoclonal anti-BCL6 antibody has been validated for WB, IHC (fp), IP and ICC. It is suitable to detect BCL6 in samples from Human.

Quick Overview for Recombinant BCL6 antibody (AA 375-425) (ABIN7455109)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BCL6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: BLR143H

Product Details anti-BCL6 Antibody

Binding Specificity: AA 375-425

Purpose: Rabbit anti-Bcl6 Recombinant Monoclonal Antibody [BLR143H]

Immunogen: between AA 375 and 425

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 6 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Alternative Name: Bcl6

Background: Background: Bcl6 is a zinc finger transcription factor and contains an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. Bcl6 can interact with a variety of POZ-containing proteins that function as transcription corepressors. Bcl6 is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL. [taken from NCBI Entrez Gene (Gene ID: 604)].

Gene ID: 604

NCBI Accession: NP_001697

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus