Progesterone Receptor antibody

Catalog No. ABIN7455133

The Mouse Monoclonal anti-Progesterone Receptor antibody has been validated for WB, IHC, IP, ICC and FACS. It is suitable to detect Progesterone Receptor in samples from Human.

Quick Overview for Progesterone Receptor antibody (ABIN7455133)

Target: Progesterone Receptor (PGR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 188

Product Details anti-Progesterone Receptor Antibody

Purpose: Mouse anti-Progesterone Receptor Monoclonal Antibody [188]

Purification: Purified

Immunogen: recombinant human Progesterone Receptor

Isotype: IgG1

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 6 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: Progesterone Receptor

Background: The progesterone receptor (PR) is a member of the steroid receptor superfamily that binds progesterone and is critical to all aspects of reproductive development and the establishment and maintenance of pregnancy. When bound by progesterone, PR enters the nucleus to function in gene-specific transcriptional activation. Progesterone receptor expression is regulated by estrogen. Recent studies have found that the status of the progesterone receptor in breast tumors may be an indicator of how tumors will respond to tamoxifen treatment.

Gene ID: 5241

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration