DNM2 antibody (C-Term)

Catalog No. ABIN7464730

The Rabbit Polyclonal anti-DNM2 antibody has been validated for WB, IF, ICC and IHC (p). It is suitable to detect DNM2 in samples from Human.

Quick Overview for DNM2 antibody (C-Term) (ABIN7464730)

Target: DNM2 (Dynamin 2 (DNM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: KO Validated

Product Details anti-DNM2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human, Mouse

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Dynamin 2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Molt-4 , Raji

Validation: KO/KD

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.44 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for DNM2

Target: DNM2 (Dynamin 2 (DNM2))

Alternative Name: dynamin 2

Background: Dynamin 2 , CMT2M , CMTDI1 , CMTDIB , DI-CMTB , DYN2 , DYNII , LCCS5,Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq]

Molecular Weight: 98 kDa

Gene ID: 1785

UniProt: P50570

Pathways: Toll-Like Receptors Cascades