MLH3 antibody (N-Term)

Catalog No. ABIN7465777

The Rabbit Polyclonal anti-MLH3 antibody has been validated for WB. It is suitable to detect MLH3 in samples from Human.

Quick Overview for MLH3 antibody (N-Term) (ABIN7465777)

Target: MLH3 (MutL Homolog 3 (MLH3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLH3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MLH3 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human MLH3. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HCT116

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.54 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for MLH3

Target: MLH3 (MutL Homolog 3 (MLH3))

Alternative Name: mutL homolog 3

Background: MutL homolog 3 , HNPCC7,This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Molecular Weight: 164 kDa

Gene ID: 27030

UniProt: Q9UHC1

Pathways: Chromatin Binding