26S Proteasome Regulatory Subunit 8 (PSMC5) antibody

Catalog No. ABIN7467907

The Mouse Monoclonal anti-26S Proteasome Regulatory Subunit 8 antibody is suitable to detect 26S Proteasome Regulatory Subunit 8 in samples from Human. It has been validated for WB.

Quick Overview for 26S Proteasome Regulatory Subunit 8 (PSMC5) antibody (ABIN7467907)

Target: 26S Proteasome Regulatory Subunit 8 (PSMC5)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Clone: 25D5

Product Details

Cross-Reactivity: Human

Purification: Protein G purified

Immunogen: Recombinant protein encoding full-length SUG1 purified from E. coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details

Target: 26S Proteasome Regulatory Subunit 8 (PSMC5)

Alternative Name: proteasome 26S subunit, ATPase 5

Background:

Synonyms: proteasome 26S subunit, ATPase 5 , S8 , SUG-1 , SUG1 , TBP10 , TRIP1 , p45 , p45/SUG

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Molecular Weight: 46 kDa

Gene ID: 5705

UniProt: P62195