DCUN1D1 antibody

Catalog No. ABIN7468232

This anti-DCUN1D1 antibody is a Rabbit Polyclonal antibody detecting DCUN1D1 in WB. Suitable for Human.

Quick Overview for DCUN1D1 antibody (ABIN7468232)

Target: DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCUN1D1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DCUN1D1 Antibody

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human DCUN1D1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A431 , Jurkat , Raji

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for DCUN1D1

Target: DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))

Alternative Name: defective in cullin neddylation 1 domain containing 1

Background:

Synonyms: defective in cullin neddylation 1 domain containing 1 , DCNL1 , DCUN1L1 , RP42 , SCCRO , SCRO , Tes3

Background: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.

Molecular Weight: 30 kDa

Gene ID: 54165

UniProt: Q96GG9