KAT2A antibody (C-Term)

Catalog No. ABIN7468506

This Rabbit Polyclonal antibody specifically detects KAT2A in WB, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for KAT2A antibody (C-Term) (ABIN7468506)

Target: KAT2A (K(lysine) Acetyltransferase 2A (KAT2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KAT2A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-KAT2A Antibody

Binding Specificity: C-Term

Specificity: This antibody was raised against KAT2A protein, and based on sequence homology, it may cross react with KAT2B protein.

Cross-Reactivity: Human, Mouse

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human GCN5. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: NIH-3T3 , JC , BCL-1 Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for KAT2A

Target: KAT2A (K(lysine) Acetyltransferase 2A (KAT2A))

Alternative Name: lysine acetyltransferase 2A

Background:

Synonyms: lysine acetyltransferase 2A , GCN5 , GCN5L2 , PCAF-b , hGCN5

Background: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]

Molecular Weight: 94 kDa

Gene ID: 2648

UniProt: Q92830

Pathways: Chromatin Binding, Tube Formation