Protein/nucleic Acid Deglycase DJ-1 (PARK7) (N-Term) antibody

Catalog No. ABIN7468819

The Rabbit Polyclonal anti-Protein/nucleic Acid Deglycase DJ-1 antibody is suitable to detect Protein/nucleic Acid Deglycase DJ-1 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for Protein/nucleic Acid Deglycase DJ-1 (PARK7) (N-Term) antibody (ABIN7468819)

Target: Protein/nucleic Acid Deglycase DJ-1 (PARK7)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: KO Validated

Product Details

Binding Specificity: N-Term

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Park7 / DJ-1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:20000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293T , A431 , HeLa , HepG2 , U87-MG , SK-N-SH , IMR32 , SK-N-AS Validation: KO/KD

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details

Target: Protein/nucleic Acid Deglycase DJ-1 (PARK7)

Alternative Name: Parkinsonism associated deglycase

Background:

Synonyms: Parkinsonism associated deglycase , DJ-1 , DJ1 , GATD2 , HEL-S-67p

Background: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Molecular Weight: 20 kDa

Gene ID: 11315

UniProt: Q99497