ARHGEF18 antibody

Catalog No. ABIN7468884

This Mouse Monoclonal antibody specifically detects ARHGEF18 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ARHGEF18 antibody (ABIN7468884)

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ARHGEF18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GT1972

Product Details anti-ARHGEF18 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Affinity purified by Protein G.

Immunogen: Recombinant protein encompassing a sequence within the center region of human ARHGEF18. The exact sequence is proprietary.

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Neuro2A , GL261 , C8D30 , NIH-3T3 , C2C12 , PC-12 , Rat-2 , 293T , A431 , HeLa , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Alternative Name: Rho/Rac guanine nucleotide exchange factor 18

Background:

Synonyms: Rho/Rac guanine nucleotide exchange factor 18 , P114-RhoGEF , RP78 , SA-RhoGEF , p114RhoGEF

Background: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Molecular Weight: 131 kDa

Gene ID: 23370

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signaling Pathway