PLA2G6 antibody (AA 651-750)

Catalog No. ABIN720281

Product Details anti-PLA2G6 Antibody

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Binding Specificity: AA 651-750

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2G6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CaI-PLA2/PLA2G6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PLA2G6

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Alternative Name: CaI-PLA2 (PLA2G6 Products)

Synonyms: zgc:77476 antibody, wu:fc06g09 antibody, PNPLA9 antibody, MGC83523 antibody, PLA2G6 antibody, BB112799 antibody, iPLA(2)beta antibody, iPLA2 antibody, iPLA2beta antibody, CaI-PLA2 antibody, GVI antibody, INAD1 antibody, IPLA2-VIA antibody, NBIA2 antibody, NBIA2A antibody, NBIA2B antibody, PARK14 antibody, PLA2 antibody, iPla2 antibody, phospholipase A2, group VI (cytosolic, calcium-independent) antibody, phospholipase A2 group VI antibody, phospholipase A2 group VI S homeolog antibody, 85/88 kDa calcium-independent phospholipase A2 antibody, phospholipase A2, group VI antibody, pla2g6 antibody, PLA2G6 antibody, pla2g6.S antibody, LOC100445065 antibody, Pla2g6 antibody

Background:

Synonyms: GVI, PLA2, INAD1, NBIA2, iPLA2, NBIA2A, NBIA2B, PARK14, PNPLA9, CaI-PLA2, IPLA2-VIA, iPLA2beta, 85/88 kDa calcium-independent phospholipase A2, Group VI phospholipase A2, GVI PLA2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, iPLA2-beta, Patatin-like phospholipase domain-containing protein 9, PLA2G6, PLPLA9

Background: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Gene ID: 8398

UniProt: O60733

Pathways: Positive Regulation of Peptide Hormone Secretion