Recombinant Hemagglutinin antibody
Quick Overview for Recombinant Hemagglutinin antibody (ABIN7487730)
Target
See all Hemagglutinin (HA) AntibodiesAntibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-HA [CR6261], Human IgG1, kappa
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Specificity
- This antibody binds hemaglutinin of most group 1 influenza viruses. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1/HA2.
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Characteristics
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Original Species of Ab: Human
Original Format of Ab: IgG1
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Purification
- Protein A affinity purified
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Immunogen
- The original antibody was isolated using phage display from the IgM+ memory B cells of a healthy individual vaccinated against influenza.
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Isotype
- IgG1 kappa
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anti-Hemagglutinin antibody (Influenza A Virus H9N2) (AA 9-28)
HA Reactivity: Influenza A Virus H9N2 WB, ICC Host: Rabbit Polyclonal unconjugated
anti-Hemagglutinin antibody (Influenza A Virus) (AA 128-143)HA Reactivity: Influenza A Virus WB, ICC Host: Rabbit Polyclonal unconjugated
anti-Hemagglutinin antibody (Influenza A Virus H1N1 (A/California/04/2009)) (AA 151-250)HA Reactivity: Influenza A Virus H1N1, Virus ELISA, WB, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Hemagglutinin antibody (Influenza A Virus H1N1 (A/Swine/Iowa/15/1930 H1N1)) (AA 205-220)HA Reactivity: Influenza A Virus H1N1 WB Host: Rabbit Polyclonal unconjugated
anti-Hemagglutinin antibody (Influenza A Virus H9N2) (AA 212-225)HA Reactivity: Influenza A Virus H9N2 WB Host: Rabbit Polyclonal unconjugated
anti-Hemagglutinin antibody (Influenza A Virus) (AA 72-88)HA Reactivity: Influenza A Virus WB Host: Rabbit Polyclonal unconjugated
anti-Hemagglutinin antibody (Influenza A Virus) (AA 102-341)HA Reactivity: Influenza A Virus ELISA, WB Host: Mouse Monoclonal HA22-C unconjugated
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Application Notes
- The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. CR6261 neutralizes multiple influenza subtypes, including H1, H2, H5, H6, H8, and H9, and protects mice from lethal challenge with H1N1 and H5N1 viruses when administered up to five days post-infection (PMID: 19251591). It is reported that Oseltamivir/Zanamivir may congruously improve the therapeutic efficacy of CR6261 (PMID: 22693576).
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Hemagglutinin (HA)
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Alternative Name
- Hemagglutinin
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Target Type
- Influenza Protein
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Background
- Hemagglutinin, Avian Influenza Virus, AIV, H1N1, H5N1, Influenza A virus
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UniProt
- Q9WFX3
Target
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