Quick Overview for Blood Group ABH antibody (PE) (ABIN7505845)
Target
Blood Group ABH
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Conjugate
This Blood Group ABH antibody is conjugated to PE
Application
Flow Cytometry (FACS)
Clone
HE-10
Purpose
Anti-Blood Group ABH PE
Specificity
The mouse monoclonal antibody HE-10 agglutinates erythrocytes of group A, and is excellent as a tumour marker in patients of blood group B and 0. It does not agglutinate erythrocytes of group B and 0. Study with specific oligosaccharides showed that the antibody HE-10 reacts with A and H antigens with chain types 3 and 4 and it does not react with A disaccharide, A trisaccharide, A type 1, A type 2, ALeb. The antibody HE-10 does not react with normal tissue sections of donors with blood group B and 0 but it reacts specifically with malignant tissues.
Purification
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Immunogen
Mixture of erythrocytes of group A1 and glycoprotein fraction isolated from saliva of secretors with blood group A.