ADAM10 antibody

Catalog No. ABIN7505861

The Mouse Monoclonal anti-ADAM10 antibody (Clone 11G2) (ABIN7505861) specifically detects ADAM10 in WB, FACS, IP, IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for ADAM10 antibody (ABIN7505861)

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADAM10 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 11G2

Product Details anti-ADAM10 Antibody

Purpose: Anti-Hu CD156c Purified

No Cross-Reactivity: Mouse

Characteristics: The mouse monoclonal antibody 11G2 recognizes an extracellular/luminal epitope of CD156c, a type I transmembrane glycoprotein, serving as a zinc-dependent metalloprotease.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Jurkat cells

Isotype: IgG1, kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-5 μg/mL, extracellular and intracellular staining.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Alternative Name: CD156c

Background: ADAM metallopeptidase domain 10,CD156c is a type I transmembrane glycoprotein with a zinc-dependent metalloprotease activity. It serves as an endopeptidase of broad specificity, which is expressed mainly in thymus, liver, and muscles. Its expression can be induced in inflamed central nervous system, and in arthritic tissues. CD156c is involved in multiple sclerosis-associated myelin degradation. It also solubilizes various membrane proteins, including CD23, CD44, CD126, CD171, ephrin-A2, and other.,ADAM10, AD10, RAK, MADM, HsT18717

Gene ID: 102

UniProt: O14672

Pathways: Notch Signaling, EGFR Signaling Pathway