GZMA antibody

Catalog No. ABIN7505978

This anti-GZMA antibody is a Mouse Monoclonal antibody detecting GZMA in IP, ICC and FACS. Suitable for Human.

Quick Overview for GZMA antibody (ABIN7505978)

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMA antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: CB9

Product Details anti-GZMA Antibody

Purpose: Anti-Hu Granzyme A Purified

Specificity: The mouse monoclonal CB9 recognizes granzyme A, a 28 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Full length human granzyme A

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 5-10 μg/mL, intracellular staining.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: Granzyme A

Background: Granzyme A,Granzyme A is a serine protease expressed in the cytoplasmic granules of T cells and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Similarly to granzyme B, granzyme A acts to destroy the target cells by proteolysis of their particular components. In case of granzyme A the targets are e.g. APEX1 (it destroys its oxidative repair activity), and nucleosome assembly protein SET (it disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA).,HFSP, CTLA3, GrA

Gene ID: 3001

UniProt: P12544

Pathways: Apoptosis