TOMM34 antibody

Catalog No. ABIN7506025

The Mouse Monoclonal anti-TOMM34 antibody is suitable to detect TOMM34 in samples from Human. It has been validated for WB, IP and ICC.

Quick Overview for TOMM34 antibody (ABIN7506025)

Target: TOMM34 (Translocase of Outer Mitochondrial Membrane 34 (TOMM34))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOMM34 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: Tomm34-4-1

Product Details anti-TOMM34 Antibody

Purpose: Anti-Hu Tomm34 Purified

Characteristics: The mouse monoclonal antibody Tomm34-4.1 recognizes an epitope within TPR2 domain of human Tomm34 protein.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Recombinant human Tomm34

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for TOMM34

Target: TOMM34 (Translocase of Outer Mitochondrial Membrane 34 (TOMM34))

Alternative Name: Tomm34

Background: Translocase of outer mitochondrial membrane 34,Tomm34 (translocase of the outer mitochondrial membrane 34) is an additional component of the cellular chaperone system involved in protein folding. As the name suggests, Tomm34 was initially identified as being involved in mitochondrial protein processing. Subsequent studies have shown that Tomm34 interacts with both Hsp70 and Hsp90 and modifies their protein folding activities. In cancer, high levels of Tomm34 have been reported in bladder, colorectal and breast cancers compared to their normal tissue counterparts. In these cancers, Tomm34 promotes colorectal cancer cell growth and is a biomarker of poor outcome in early invasive breast cancer and bladder cancer. As a tumour-associated protein, Tomm34 peptide vaccination is under investigation as a therapeutic option for colorectal cancer, with significant Tomm34 cytotoxic T-lymphocyte (CTL) response observed.,URCC3, HTOM34P

Gene ID: 10953

UniProt: Q15785