FGFR3 antibody

Catalog No. ABIN7539297

This Escherichia coli (E. coli) Monoclonal antibody specifically detects FGFR3 in Neut. It exhibits reactivity toward Human.

Quick Overview for FGFR3 antibody (ABIN7539297)

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Fragment: Fab fragment

Reactivity: Human

Host: Escherichia coli (E. coli)

Clonality: Monoclonal

Conjugate: This FGFR3 antibody is un-conjugated

Application: Neutralization (Neut)

Product Details anti-FGFR3 Antibody

Purpose: FGFR-3 neutralizing antibody antibody

Specificity: Chromosomal location:4p16.3

Purification: Ion exchange chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Storage: 4 °C,-20 °C

Storage Comment: Lyophilized samples are stable for up to a year at -20°C. Upon reconstitution, the Fab is stable for up to 1 month at 4°C or up to 1 year at -20°C.

Expiry Date: 24 months

Target Details for FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Alternative Name: FGFR-3

Background: FGFR3, ACH, CEK2, JTK4, CD333, HSFGFR3EX,Fibroblast Growth Factor Receptor 3 (FGF R3) is a type I transmembrane tyrosine kinase receptor that binds FGF ligands along with heparin or heparin sulfateproteoglycans as cofactors. A segment of the membrane proximal Ig-like domain can be encoded by two different exons resulting in (IIIb) or (IIIc) isoforms. The IIIb or IIIc isoforms recognize FGF1, 2, 4, 8b, 8e, 8f, 9, and 17b. FGF R3 plays a role in skeletal, brain, lung, intestine, kidney, and skin development.

Gene ID: 2261

NCBI Accession: NM_000142, NP_000133

UniProt: P22607

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding