CCR7 antibody

Catalog No. ABIN7539624

This Mouse Monoclonal antibody specifically detects CCR7 in FACS. It exhibits reactivity toward Human.

Quick Overview for CCR7 antibody (ABIN7539624)

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR7 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: G043H7

Product Details anti-CCR7 Antibody

Purpose: AF/LE Purified Anti-Human CD197 Antibody [G043H7]

Specificity: Human

Purification: Protein A/G Purified

Endotoxin Level: Low Endotoxin: < 1.0 EU per mg of the antibody as determined by the LAL method.

Immunogen: Recombinant Human CD197 protein

Isotype: IgG2a, kappa

Application Details

Application Notes: FCM:2 μg/mL(1x10^5-5x10^5 cells)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: ≥ 1 mg/mL

Buffer: Sterile PBS.

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Target Details for CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Alternative Name: CD197

Background: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.

Gene ID: 1236

UniProt: P32248

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process