NOTCH2 antibody (AA 1391-1677)

Catalog No. ABIN7539763

The Mouse Monoclonal anti-NOTCH2 antibody has been validated for ELISA, IHC, FACS and ICC. It is suitable to detect NOTCH2 in samples from Human.

Quick Overview for NOTCH2 antibody (AA 1391-1677) (ABIN7539763)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOTCH2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 2D1B2

Product Details anti-NOTCH2 Antibody

Binding Specificity: AA 1391-1677

Purpose: NOTCH2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NOTCH2 (AA: 1391-1677) expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/200

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Alternative Name: NOTCH2

Background: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 265.4 kDa

Gene ID: 4853

Pathways: Notch Signaling, Stem Cell Maintenance