NOTCH4 antibody (AA 118-357)

Catalog No. ABIN7539800

This anti-NOTCH4 antibody is a Mouse Monoclonal antibody detecting NOTCH4 in ELISA, ICC and FACS. Suitable for Human.

Quick Overview for NOTCH4 antibody (AA 118-357) (ABIN7539800)

Target: NOTCH4 (Notch 4 (NOTCH4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOTCH4 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 1B2B6

Product Details anti-NOTCH4 Antibody

Binding Specificity: AA 118-357

Purpose: NOTCH4 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NOTCH4 (AA: 118-357) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/200

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for NOTCH4

Target: NOTCH4 (Notch 4 (NOTCH4))

Alternative Name: NOTCH4

Background: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Molecular Weight: 209.6 kDa

Gene ID: 4855

UniProt: Q99466

Pathways: Notch Signaling