Mre11 antibody (AA 182-582)

Catalog No. ABIN7539803

This anti-Mre11 antibody is a Mouse Monoclonal antibody detecting Mre11 in ELISA, IHC and FACS. Suitable for Human and Rat.

Quick Overview for Mre11 antibody (AA 182-582) (ABIN7539803)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 4D2B6

Product Details anti-Mre11 Antibody

Binding Specificity: AA 182-582

Purpose: MRE11 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Alternative Name: MRE11

Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Molecular Weight: 80.6 kDa

Gene ID: 4361

UniProt: P49959

Pathways: DNA Damage Repair