Thrombomodulin antibody (FITC)

Catalog No. ABIN7540416

The Mouse Monoclonal anti-Thrombomodulin antibody has been validated for FACS. It is suitable to detect Thrombomodulin in samples from Human.

Quick Overview for Thrombomodulin antibody (FITC) (ABIN7540416)

Target: Thrombomodulin (THBD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thrombomodulin antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Clone: M80

Product Details anti-Thrombomodulin Antibody (FITC)

Purpose: Anti-Hu CD141 FITC

Specificity: The mouse monoclonal antibody M80 recognizes an extracellular epitope of CD141, a 75 kDa transmembrane glycoprotein expressed mainly on macrophages, monocytes, platelets and endothelial cells.

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: MV4-11 cell line

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for Thrombomodulin

Target: Thrombomodulin (THBD)

Alternative Name: CD141

Background:

NCBI Full Gene Name: thrombomodulin

Description: CD141, also known as thrombomodulin or fetomodulin, is a single chain type I transmembrane glycoprotein serving as a receptor for thrombin and as an important cofactor in the protein C anticoagulant system, but it is also involved in embryonic and atherosclerotic plaque development. CD141 is expressed mainly on macrophages, monocytes, a subpopulation of myeloid dendritic cells, on platelets and endothelial cells, but also e.g. on keratinocytes (epithelium). After binding to thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. Mutations in the CD141 gene can cause a thromboembolic disease known as inherited thrombophilia.

Other names: Thrombomodulin, fetomodulin, THBD, THRM, THPH12, TM

Gene name: THBD

Gene ID: 7056

UniProt: P07204