HHV8 LANA1 antibody

Catalog No. ABIN7540661

Supplier Product No.: mob395-01

This Rat Monoclonal antibody specifically detects HHV8 LANA1 in IHC. It exhibits reactivity toward Herpes Simplex Virus (HSV).

Quick Overview for HHV8 LANA1 antibody (ABIN7540661)

Target: HHV8 LANA1

Reactivity: Herpes Simplex Virus (HSV)

Host: Rat

Clonality: Monoclonal

Application: Immunohistochemistry (IHC)

Clone: LN53

Product Details

Supplier Product No.: mob395-01

Supplier: Rockland

Purpose: Herpesvirus 8 Monoclonal Antibody

Cross-Reactivity (Details): This antibody reacts with Herpesvirus 8.

Purification: The antibody was clarified from tissue culture supernatant.

Immunogen: Anti-Herpesvirus 8 Antibody was produced in rats by repeated immunizations with recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8.

Isotype: IgG3

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:50-1:100

Comment:

Anti-Herpesvirus 8 (RAT) Monoclonal Antibody was tested in IHC-P with positive control Karposi sarcoma tissues. Cellular Localization: Nuclear. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. This antibody is suitable for use until the expiration date when stored at 2-8°C. Do not use product after the expiration date printed on vial. If reagents are stored under conditions other than those specified here, they must be verified by the user. Diluted reagents should be used promptly. Unused portions of antibody preparation should be discarded after one day. The presence of precipitate or an unusual odor indicates that the antibody is deteriorating and should not be used.

Target Details

Target: HHV8 LANA1

Background: Herpes, Herpesvirus, HHV8, latent nuclear antigen, LNA, viral gene orf 73,HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients, kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. HHV 8 is the likely etiological agent of Kaposi's sarcoma.