Recombinant Transferrin Receptor antibody

Catalog No. ABIN7543001

This Rabbit Chimeric antibody specifically detects Transferrin Receptor in FACS, WB, IF, IHC (fro) and in vivo. It exhibits reactivity toward Rat.

Quick Overview for Recombinant Transferrin Receptor antibody (ABIN7543001)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Antibody Type: Recombinant Antibody

Reactivity: Rat

Host: Rabbit

Clonality: Chimeric

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), In vivo Studies (in vivo)

Clone: OX-26

Product Details anti-Transferrin Receptor Antibody

Purpose: Anti-CD71 [OX-26], Rabbit IgG, kappa

Specificity: This antibody binds to rat CD71, the transferrin recepetor.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: OX-26 was prepared by immunizing BALB/c mice with rat transferrin receptor.

Isotype: IgG kappa

Application Details

Application Notes: This antibody binds to the rat transferrin receptor, and in its original mouse IgG2a version, it was shown to be taken up into the brain across the blood-brain barrier (Moss 2001). Mutational screening showed that this process is dependent on the antibody's affinity for its target (Haqqani 2018). The antibody can also be used in flow cytometry, immunofluorescence, and western blot, and it may also be used in frozen-section IHC.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: CD71

Background: Transferrin receptor, TfR, p90, T9, TFR1, OX26, MRC OX26, MRC OX-26

UniProt: Q99376

Pathways: Transition Metal Ion Homeostasis