Recombinant CD2 antibody

Catalog No. ABIN7543003

This anti-CD2 antibody is a Rabbit Chimeric antibody detecting CD2 in FACS and BR. Suitable for Rat.

Quick Overview for Recombinant CD2 antibody (ABIN7543003)

Target: CD2

Antibody Type: Recombinant Antibody

Reactivity: Rat

Host: Rabbit

Clonality: Chimeric

Conjugate: This CD2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Blocking Reagent (BR)

Clone: OX-34

Product Details anti-CD2 Antibody

Purpose: Anti-CD2 [OX-34], Rabbit IgG, kappa

Specificity: OX-34 binds specifically to rat CD2. CD2 is type I membrane protein involved in triggering of T-cells (cytoplasmic domain is involved in signaling function) and is expressed on thymocytes, peripheral T cells, dendritic epidermal T cells, macrophages in the spleen, and NK cells.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: OX-34 was prepared by immunizing mice with T blasts prepared in mixed lymphocyte reactions with purified rat T helper cells against irradiated spleen.

Isotype: IgG kappa

Application Details

Application Notes: Ox34 blocks CD48 binding to CD2 causing partial block of T cell activation, OX34 can be used to deplete peripheral T cells (used to prevent allograft rejection in vivo).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD2

Target: CD2

Alternative Name: CD2

Background: LFA-2, LFA2, OX-34 antigen, OX34 antigen, T-cell surface antigen T11/Leu5, T cell surface antigen T11/Leu5, OX34, MRC OX34, MRC OX-34

UniProt: P08921