Recombinant NCR1 antibody

Catalog No. ABIN7543305

The Human Chimeric anti-NCR1 antibody has been validated for FACS, IP and IF. It is suitable to detect NCR1 in samples from Human.

Quick Overview for Recombinant NCR1 antibody (ABIN7543305)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Human

Clonality: Chimeric

Conjugate: This NCR1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: Bab281

Product Details anti-NCR1 Antibody

Purpose: Anti-NKp46 [Bab281], Human IgG1, kappa

Specificity: The antibody is specific for human NKp46. The antibody cross-reacts with macaque NK46 but does not cross-react with mouse NKp46. NKp46 is a receptor expressed by NK cells.

Cross-Reactivity: Macaque

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing Balb/c mice with recombinant human NKp46 protein.

Isotype: IgG1 kappa

Application Details

Application Notes: The antibody was used to immunoprecipitate NKp46 Molecules from NK and COS-7 cells (Pessino et al., 1998, PMID 9730896 and Cantoni et al. 1999, PMID: 10049942). NK cells were analyzed for NKp46 surface expression by immunofluorescence and Flow Cytometry analysis using the antibody (Sivori et al., 1999, PMID: 10359120). The antibody binding to NKp46 promoted an increase of cytolytic activity in NK cells (Sivori et al., 1997, PMID: 9314561 and Sivori et al., 1999, PMID: 10359120).

Comment:

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Alternative Name: NKp46

Background: Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein, NK-p46, hNKp46, CD335

UniProt: O76036

Pathways: Regulation of Leukocyte Mediated Immunity