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Recombinant TLR7 antibody

The Rabbit Chimeric anti-TLR7 antibody has been validated for ELISA and FACS. It is suitable to detect TLR7 in samples from Human.
Catalog No. ABIN7543380

Quick Overview for Recombinant TLR7 antibody (ABIN7543380)

Target

See all TLR7 Antibodies
TLR7 (Toll-Like Receptor 7 (TLR7))

Antibody Type

Recombinant Antibody

Reactivity

  • 95
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  • 9
  • 3
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  • 2
  • 1
  • 1
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  • 1
Human

Host

  • 92
  • 20
Rabbit

Clonality

  • 81
  • 31
Chimeric

Conjugate

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  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
This TLR7 antibody is un-conjugated

Application

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  • 1
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ELISA, Flow Cytometry (FACS)

Clone

LTM3
  • Purpose

    Anti-TLR7 [LTM3], Rabbit IgG, kappa

    Specificity

    This antibody binds human toll-like receptor 7 (TLR7). It also cross reacts with monkey TLR7. It is an endosomal receptor that plays a key role in innate and adaptive immunity. It also controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. TLR7 is considered to be a useful marker in indicating pathological condition of autoimmune diseases.

    Cross-Reactivity

    Monkey

    Characteristics

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Purification

    Protein A affinity purified

    Immunogen

    The original antibody was generated by immunizing TLR7 deficient BALB/mice with Ba/F3 cell line expressing hTLR7-Flag-Hisx6/hUnc93B1-HAx2 mixed with a suitable adjuvant.

    Isotype

    IgG kappa
  • Application Notes

    This antibody was used in combination with another anti-TLR7 antibody called rE3 to detect human TLR7 in a sandwich ELISA. LTM3 was used as used as a capturing antibody and biotinylated rE3 antibody (rE3-bio) was used a detecting antibody. This antibody can be used for the detection of human TLR7 in serum or plasma derived from human peripheral blood. The binding ability of this antibody for Ba/F3 cell line expressing human TLR7, mouse TLR7 and monkey TLR7 was checked using flow cytometry. This antibody can successfully detect human and monkey TLR7, but not mouse TLR7 in a flow cytometry (US20210199667).

    Comment

    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

    Restrictions

    For Research Use only
  • Concentration

    1 mg/mL

    Buffer

    PBS with 0.02 % Proclin 300.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target

    TLR7 (Toll-Like Receptor 7 (TLR7))

    Alternative Name

    TLR7

    Background

    Toll-like receptor 7, UNQ248/PRO285

    UniProt

    Q9NYK1

    Pathways

    TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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