Recombinant Progesterone Receptor antibody

Catalog No. ABIN7543415

This Mouse Chimeric antibody specifically detects Progesterone Receptor in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant Progesterone Receptor antibody (ABIN7543415)

Target: Progesterone Receptor (PGR)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Chimeric

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 14B3

Product Details anti-Progesterone Receptor Antibody

Purpose: Anti-Progesterone Receptor [14B3], Mouse IgG1, kappa

Specificity: The antibody is specific for PR protein. PR is a protein molecule, a cellular core receptor belonging to a steroidal superfamily, which can be bonded to the corresponding hormone to form a hormone-receptor complex, enabling hormones to exert their biological effects.

Characteristics:

Original Species of Ab: Rabbit

Original Format of Ab: IgG

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing rabbits with PR protein.

Isotype: IgG1 kappa

Application Details

Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis (affinity constant of 1.82 x 10^10 M-1). The antibody specifically detected PR protein in Western blot analysis. The antibody 14B3 and the commercial antibody 1E2 were used to stain breast cancer and endometrial. Results showed the antibody specificity is comparable to the commercial antibody. Further, the sensitivity of the antibody 14B3 was higher than the commercial antibody (CN113583132A).

Comment:

This chimeric mouse antibody was made using the variable domain sequences of the original Rabbit IgG format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: Progesterone Receptor

Background: PR, Nuclear receptor subfamily 3 group C member 3

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration