Recombinant NCR1 antibody

Catalog No. ABIN7543465

This anti-NCR1 antibody is a Rat Monoclonal antibody detecting NCR1 in FACS and Act. Suitable for Mouse.

Quick Overview for Recombinant NCR1 antibody (ABIN7543465)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This NCR1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Activation (Act)

Clone: 29A1-4

Product Details anti-NCR1 Antibody

Purpose: Anti-Nkp46 [29A1.4], Rat IgG2a, kappa

Specificity: This antibody is specific for mouse NKp46-Fc.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing rats with mouse NKp46-Fc recombinant protein.

Isotype: IgG2a kappa

Application Details

Application Notes: The original format of this antibody was used in an FC analysis to detect NKp46 expression on NK cells and to activate NK in an NK cell stimulation assay (Walzer et al., 2007, PMID: 17360655). This antibody was used as a component of bispecific NKCEs (Natural Killer Cell Engagers) to redirect the cytotoxic activity of NK cells towards human CD20-expressing tumor cells in a transplantable xenogeneic in vivo solid tumor model (Gauthier et al., 2019, PMID: 31155232).

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Alternative Name: Nkp46

Background: CD335, NK-p46, NKp46, mNKp46, mAR-1, Activating receptor 1, Lymphocyte antigen 94, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1

UniProt: Q8C567

Pathways: Regulation of Leukocyte Mediated Immunity