Adrenomedullin antibody (AA 122-140) (Biotin)

Catalog No. ABIN723517

This Rabbit Polyclonal antibody specifically detects Adrenomedullin in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Rat.

Quick Overview for Adrenomedullin antibody (AA 122-140) (Biotin) (ABIN723517)

Target: Adrenomedullin (ADM)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adrenomedullin antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Adrenomedullin Antibody (Biotin)

Binding Specificity: AA 122-140

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Adrenomedullin

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Adrenomedullin

Target: Adrenomedullin (ADM)

Alternative Name: Adrenomedullin

Target Type: Hormone

Background:

Synonyms: AM, PAMP, ADM, Adrenomedullin

Background: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene ID: 133

UniProt: P35318

Pathways: Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation