FADD antibody

Catalog No. ABIN7566417

This anti-FADD antibody is a Mouse Monoclonal antibody detecting FADD in WB, ELISA and IP. Suitable for Human.

Quick Overview for FADD antibody (ABIN7566417)

Target: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FADD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Clone: 1C4

Product Details anti-FADD Antibody

Purpose: anti-FADD (human), mAb (1C4)

Characteristics:

Monoclonal Antibody. Recognizes the C-terminus of human FADD only in its unphosphorylated form. Application: ELISA,IP,WB. Clone: 1C4. Isotype: Mouse IgG1. Liquid. In PBS and 0.02 % sodium azide. FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells.

FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells.

Purification: Puified

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human FADD.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Target Details for FADD

Target: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Alternative Name: FADD

UniProt: Q13158

Pathways: Apoptosis, TLR Signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades