Caspase 1 (p10) antibody (AA 320-404) (HRP)

Catalog No. ABIN725789

The Rabbit Polyclonal anti-Caspase 1 (p10) antibody is suitable to detect Caspase 1 (p10) in samples from Human, Mouse, Rat and Chicken. It has been validated for WB, ELISA, IHC (fro) and IHC (p).

Quick Overview for Caspase 1 (p10) antibody (AA 320-404) (HRP) (ABIN725789)

Target: Caspase 1 (p10) (CASP-1 (p10))

Reactivity: Human, Mouse, Rat, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 1 (p10) antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Caspase 1 (p10) Antibody (HRP)

Binding Specificity: AA 320-404

Cross-Reactivity: Chicken, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Caspase-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Caspase 1 (p10)

Target: Caspase 1 (p10) (CASP-1 (p10))

Alternative Name: Caspase-1 P10

Background:

Synonyms: ICE, P45, IL1BC, Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, CASP1, IL1BCE

Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Gene ID: 834

UniProt: P29466