NPTX2 antibody (Secreted)

Catalog No. ABIN7886700

The Rabbit Polyclonal anti-NPTX2 antibody (ABIN7886700) specifically detects NPTX2 in WB and IHC. The antibody is reactive with Mouse samples.

Quick Overview for NPTX2 antibody (Secreted) (ABIN7886700)

Target: NPTX2 (Neuronal Pentraxin II (NPTX2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPTX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NPTX2 Antibody

Binding Specificity: AA 186-198, Secreted

Purpose: A Rabbit Polyclonal antibody to Neuronal Pentraxin 2 (NPTX2)

Sequence: (C)HNETSAHRQK TES

Predicted Reactivity: Human - identical,rat - 12 out of 13 amino acid residues identical

Characteristics: Anti-Neuronal Pentraxin 2 (NPTX2) Antibody (ABIN7581924) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPTX2 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)HNETSAHRQKTES, corresponding to amino acid residues 186 - 198 of mouse NPTX2 

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for NPTX2

Target: NPTX2 (Neuronal Pentraxin II (NPTX2))

Alternative Name: NPTX2

Background:

Synonyms: Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP

Description: Neuronal pentraxin 2 (NP2), also known as NPTX2, NP-II, and neuronal activity-regulated pentraxin (Narp), is a calcium-dependent lectin secreted protein member of the pentraxin family involved in synaptic plasticity and excitatory homeostasis.1,2NP2 is part of the neuronal pentraxin family that includes two other members: Neuronal Pentraxin 1 (NP1) and Neuronal Pentraxin Receptor (NPTXR). The pentraxin superfamily members are arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain 2,3.NP2 is widely expressed in the brain, especially in the hippocampus, dentate gyrus, cerebellum, and cerebral cortex regions, as well as in the testis, pancreas, liver, heart, and skeletal muscle.2,3NP2 interacts with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which are crucial for excitatory neurotransmission in the brain. By binding to AMPA receptors, NP2 influences their trafficking and localization at synapses, affecting the strength of excitatory synaptic transmission 2,3.Given its presence in brain regions associated with learning and memory, alterations in NP2 levels or function have been implicated in cognitive processes. Dysregulation of NP2 has been observed in various neurological disorders, suggesting its potential importance in maintaining cognitive function.4-6Abnormalities in NP2 expression have been linked to neurodegenerative disorders, including Alzheimer's disease. Changes in NP2 levels may contribute to synaptic dysfunction and cognitive decline observed in these conditions.4-6

Gene ID: 53324

UniProt: O70340