Beclin 1 antibody

Catalog No. ABIN7595319

The Chicken Polyclonal anti-Beclin 1 antibody has been validated for WB and IHC. It is suitable to detect Beclin 1 in samples from Mouse.

Quick Overview for Beclin 1 antibody (ABIN7595319)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity: Mouse

Host: Chicken

Clonality: Polyclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Beclin 1 Antibody

Purpose: Chicken antibody to Beclin-1

Specificity: Specific for Beclin-1.

Cross-Reactivity: Human, Marmoset, Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: Purified IgY

Immunogen: Truncated recombinant mouse Beclin-1 conjugated to blue carrier protein has been used as the antigen. The antigen shares 99% identity with human and rat sequences.

Isotype: IgY

Application Details

Application Notes: IHC WB. Use at a dilution of 1 : 1000. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term.

Expiry Date: 12 months

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: Beclin-1

Background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation metamorphosis non-apoptotic cell death and aging. Reduced levels of autophagy have been described in some malignant tumors and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy. SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane, Peripheral membrane protein. Note: Expressed in dendrites and cell bodies of cerebellar Purkinje cells TISSUE SPECIFICITY: Ubiquitous

Pathways: Autophagy