IL2 Receptor beta antibody (Biotin)

Catalog No. ABIN7595391

The Mouse Monoclonal anti-IL2 Receptor beta antibody has been validated for FACS and IP. It is suitable to detect IL2 Receptor beta in samples from Human.

Quick Overview for IL2 Receptor beta antibody (Biotin) (ABIN7595391)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL2 Receptor beta antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: TU27

Product Details anti-IL2 Receptor beta Antibody (Biotin)

Purpose: Anti-Hu CD122 Biotin

Specificity: The mouse monoclonal antibody TU27 recognizes an extracellular epitope of CD122 (IL-2R beta), a 70-75 kDa type I transmembrane glycoprotein constitutively expressed by NK cells and a T cell subset, and upregulated upon activation.

Purification: Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Immunogen: TL-Mor cell line

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: CD122

Background: CD122 (IL-2/IL-15R beta) constitutes together with CD132 (common gamma chain) and with CD25 (IL-2/IL15R alpha) the intermediate (CD122+CD132) and the high affinity (CD122+CD132+CD25) IL-2 and IL-15 receptor complex. CD122 is expressed on NK cells and lymphocytes, but at low level, unless the cell is activated. The cytoplasmic part of CD122 binds to Src-family and Jak-family kinases. The biological effect of CD122 ligation depends on whether IL-2 or IL-15 is bound to the receptor complex.

Gene ID: 3560

UniProt: P14784

Pathways: JAK-STAT Signaling, Growth Factor Binding