DREAM antibody (AA 1-256) (FL490)

Catalog No. ABIN7595409

The Mouse Monoclonal anti-DREAM antibody has been validated for IHC and ICC. It is suitable to detect DREAM in samples from Rat.

Quick Overview for DREAM antibody (AA 1-256) (FL490) (ABIN7595409)

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This DREAM antibody is conjugated to FL490

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: K66-38

Product Details anti-DREAM Antibody (FL490)

Binding Specificity: AA 1-256

Purpose: Anti-KChIP3 K+ Channel Antibody FL490 Conjugate

Specificity: No off-targets reported for rat KChIPs 1,2, 4

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-KChIP3 K+ channel mouse monoclonal primary antibody is produced in-house from hybridoma clone K66/38. It is KO validated, detects human, mouse, and rat KChIP3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our KChIP3 K+ channel mouse monoclonal primary antibody from hybridoma clone K66/38. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 1-256 (full length) of rat Calsenillin/DREAM/KChIP3 (accession number Q9JM47) produced recombinantly in E. Coli

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Alternative Name: KChIP3 K+ channel

Background:

Synonyms: Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)

Target Description: Kchip3 potassium channel, also known as Kv channel-interacting protein 3, Kcnip3, DREantagonist modulator and Dream is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin or neuronal calcium sensor (NCS) family branch of the EF-hand superfamily. Kchip3 is an integral subunit component of native Kv4 channel complexes that may regulate A-type currents and function as a calcium regulated transcriptional repressor. Kchip3 is detected in brain, specifically in the cortex, thalamus, dentate gyrus and cerebellum and can be found throughout the cell. It is also found in other tissues at low levels. Diseases associated with KCNIP3 include alzheimer disease.

Gene Name Alternatives: Kcnip3 Csen Dream Kchip3

Molecular Weight: 34 kDa