ADAM22 antibody (AA 757-857) (FL490)

Catalog No. ABIN7595467

This anti-ADAM22 antibody is a Mouse Monoclonal antibody detecting ADAM22 in IHC and ICC. Suitable for Mouse.

Quick Overview for ADAM22 antibody (AA 757-857) (FL490) (ABIN7595467)

Target: ADAM22 (ADAM Metallopeptidase Domain 22 (ADAM22))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADAM22 antibody is conjugated to FL490

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N46-30

Product Details anti-ADAM22 Antibody (FL490)

Binding Specificity: AA 757-857

Purpose: Anti-ADAM22 (Cytoplasmic) Antibody FL490 Conjugate

Specificity: No off-targets reported

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-ADAM22 (cytoplasmic) mouse monoclonal primary antibody is produced in-house from hybridoma clone N46/30. It is KO validated, detects human, mouse, and rat ADAM22 (cytoplasmic), and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our ADAM22 (cytoplasmic) mouse monoclonal primary antibody from hybridoma clone N46/30. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 757-857 (cytoplasmic region) of mouse ADAM22 (accession number Q9R1V6) produced recombinantly in E. Coli

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for ADAM22

Target: ADAM22 (ADAM Metallopeptidase Domain 22 (ADAM22))

Alternative Name: ADAM22

Background:

Synonyms: Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22)

Target Description: ADAM22 is a member of the ADAM (a disintegrin and metalloproteinase) family and predominantly expressed in brain. ADAM 22 is non-catalytic unlike other proteins in the family as it does not contain a zinc binding domain. ADAM22 is a post synaptic neuron receptor for LGI 1 and also binds LGI4. ADAM22 serve as an integrin ligand. Mutations in ADAM22 are implicated in early infantile epileptic encephalopathy-61 and Brachydactyly type C.

Gene Name Alternatives: Adam22

Molecular Weight: 90 kDa