MESDC2 antibody (AA 30-95) (FL650)

Catalog No. ABIN7595839

This anti-MESDC2 antibody is a Mouse Monoclonal antibody detecting MESDC2 in IHC and ICC. Suitable for Mouse.

Quick Overview for MESDC2 antibody (AA 30-95) (FL650) (ABIN7595839)

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MESDC2 antibody is conjugated to FL650

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N88-12

Product Details anti-MESDC2 Antibody (FL650)

Binding Specificity: AA 30-95

Purpose: Anti-MESD Antibody FL650 Conjugate

Specificity: No off-targets reported

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-MESD mouse monoclonal primary antibody is produced in-house from hybridoma clone N88/12. It detects human, mouse, and rat MESD, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our MESD mouse monoclonal primary antibody from hybridoma clone N88/12. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 30-95 and 118-180 (lacking VSD domain) of mouse MESD (accession number Q9ERE7) produced recombinantly in E. Coli

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for MESDC2

Target: MESDC2 (Mesoderm Development Candidate 2 (MESDC2))

Alternative Name: MESD

Background:

Synonyms: LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein)

Target Description: Mesoderm Development LRP Chaperone is encoded by the gene MESD. MESD is a member of the MESD family. MESD is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). MESD acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. MESD is essential for the specification of embryonic polarity and mesoderm induction. MESD plays an essential role neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. MESD is expressed in many tissues, but not in skeletal muscles. Diseases associated with MESD include Osteogenesis Imperfecta, Type Xx and Epilepsy, Nocturnal Frontal Lobe, 2.

Gene Name Alternatives: Mesd Mesdc2

Molecular Weight: 26 kDa