EpCAM antibody (AA 24-265)

Catalog No. ABIN7596020

The Mouse Monoclonal anti-EpCAM antibody (Clone AT36F10) (ABIN7596020) specifically detects EpCAM in WB, IF, ELISA and ICC. The antibody is reactive with Human samples.

Quick Overview for EpCAM antibody (AA 24-265) (ABIN7596020)

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EpCAM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Clone: AT36F10

Product Details anti-EpCAM Antibody

Binding Specificity: AA 24-265

Purpose: Human EpCAM/TROP-1 antibody

Purification: Purified

Immunogen: Recombinant human EpCAM/TROP-1 (24-265aa) purified from E. coli

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for EpCAM

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Alternative Name: EpCAM/TROP-1

Background: Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. EPCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EPCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EPCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EPCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.

NCBI Accession: NP_002345