NCR1 antibody (AA 22-255)

Catalog No. ABIN7596031

The Mouse Monoclonal anti-NCR1 antibody has been validated for FACS and ELISA. It is suitable to detect NCR1 in samples from Human.

Quick Overview for NCR1 antibody (AA 22-255) (ABIN7596031)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NCR1 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: N1D9

Product Details anti-NCR1 Antibody

Binding Specificity: AA 22-255

Purpose: Human NKp46/NCR1 antibody

Purification: protein-A affinity chromatography

Immunogen: Recombinant human Nkp46/NCR1 (22-255aa) purified from E. coli.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Alternative Name: NKp46/NCR1

Background: A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk cell-specific molecule involved in human Nk cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appearto be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in Nk cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.

NCBI Accession: NP_004820

Pathways: Regulation of Leukocyte Mediated Immunity