TLR7 antibody (AA 451-500)
Quick Overview for TLR7 antibody (AA 451-500) (ABIN7596035)
Target
See all TLR7 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Binding Specificity
- AA 451-500
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Purpose
- Human TLR7 antibody
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Purification
- protein-A affinity chromatography
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Immunogen
- Recombinant human TLR7 (451-500aa) purified from E. coli.
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Isotype
- IgG1 kappa
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
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- TLR7 (Toll-Like Receptor 7 (TLR7))
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Alternative Name
- TLR7
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Background
- TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity byrecognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine richrepeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptormolecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7(hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7, 8 genes are located on the sexchromosome X. hTLR7 may play an important role in detecting and combating viral infections.
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NCBI Accession
- NP_057646
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Pathways
- TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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